Trouble is the first single from Pink's third album, Try This. It was released on 8th September 2003 and written by Tim Armstrong and Pink. It was was moderately successful, reaching number two on the Canadian Singles Chart on November 29, 2003. Elsewhere it was less successful and in the U.S. it failed to become a hit. The song won her a Grammy for Best Female Rock Vocal Performance in 2004.

The song was featured in the films White Chicks (2004), The Princess Diaries 2: Royal Engagement (2004), Miss Congeniality 2: Armed and Fabulous (2005). It is also featured in the teaser trailer for Disney's film Tangled, which is scheduled for release in 2010.

The song's music video is western-themed. In it, Pink rides her horse into a small town named Sharktown. Upon seeing several horses tied up, she starts a brawl with the men nearby. She then enters a saloon and orders a drink. The bartender looks to the sheriff (Jeremy Renner), who has been watching Pink since she arrived. When the sheriff indicates "no," the bartender refuses to serve Pink, causing her to leap over the counter, knock down the bartender, and start another brawl.

The sheriff breaks a bottle on her head and then has her carried into a jail cell. Pink seduces the sheriff, who lets her out of the cell, and transfers her own handcuffs to the sheriff. She enters the bar for another fight, and she and several other women (specifically, the Pussycat Dolls) begin dancing on top of the bar counter. After freeing the horses from their stable, Pink defeats the sheriff in a fight using whips and rides out of town.

The child actress, Kelsey Lewis, who features in the video also features in Pink's video for Family Portrait.